In 1977, I wrote a paper on a genetic model for the cause of cancer. The paper was not published, but was distributed to a small group. In 1991, it was transferred to a word processing document. The introduction was updated, spelling was corrected elsewhere, several diagrams were redrawn with a plotter, but no other changes were made. Now it has been transferred to an HTML document and it is available at:
In the paper I was describing a counter mechanism for the cell's life span and how this counter can cause cancer. I described it as having a coding of CGT, (which we now know is wrong) and as an incremental counter. But, I did say the following in the paper:
"...it is identical in all tissues of the body. One of its primary functions is to control when a cell divides and how many times it will divide (or its life span). Unlocking the secrets of this gene indeed, is the secret to aging, the secret to immortality."
"...the CGT is the counter mechanism and its occurrence from tissue group to tissue group varies."
"...it may occur 100, 1000, or 10,000 times within a cell."
What I was describing is now known as the telomere -TTAGGG, a decremental counter controlling the number of cell divisions. Equally important, I described how the telomere subunit is involved in the initiation of cancer. In the paper I show that cancer is initiated by the mutation of the telomere subunit sequence. I have not seen a paper describing the disposition of the deleted telomere subunit(s). It probably has been done, but it needs to be rechecked.
I theorize that there is an enzyme I call the "Where To Go" (WTG) enzyme. After cell division WTG picks up or transcribes the released telomere subunit(s) and initiates normal cell functioning. If the telomere subunit is mutated then one of the following things may happen depending on the mutated sequence:
1.) The cell may die.
2.) An oncogene may be initialized, but is still under normal telomere counting.
3.) Embryonic growth may be initialized, but is still under normal telomere counting.
4.) Telomerase may be initialized.
With a corrupted subunit anything may be initialized. Someone with the facilities should create a string of labeled and non TTAGGG subunits and insert it in a living cell and observe the outcome when the labeled sequence becomes active. This is a lot of work as there are 4,095 possibilities.
A mutated telomere subunit is the loose cannon in the cell.
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